116 CE - The Roman Empire is in its largest extent:

64-65 CE - Annexation of Alpes Cottiae (parts of present France, Italy, and Switzerland)
74 CE - Annexation of the Agri Decumates (now southwestern Germany)
85 CE - Division of Moesia into two provinces in superior (upper) and inferior (lower)
105 CE - Annexation of the kingdom of Nabatea as Province of Arabia Petra
106 CE - Conquest of Dacia
107 CE - Division of Pannonia into two provinces superior (upper) and inferior (lower)
114 CE - Annexation of Armenia
116 CE - Conquest of Mesopotamia
116 CE - Conquest of Assyria